I'm afraid that there is no solution... There is lot's of people reporting problems with W10 and Prolific devices (based on popular PL2303 adapter). Myself, I've the same problems with scrolling LED Badges, and USB to COM dongles. All this devices use a PL2303 to provide a connection to an USB port, but inside, they are RS232-like interface build (and appear as a COM port in your operating system). When you plug the device into USB, it is well recognized by W10 and it try to load the Prolific driver. This work fine, but looking at the configuration panel, you will then notice that there is an error code 10 and the driver is not working properly.
PL2303 Windows Driver Download USB to UART RS232 Serial. Download Driver Setup Program: Driver Installer File. OS Support; Standard Driver. (Chip Rev A) USB to Serial Controller ICs using Prolific's trademark logo, brandname, and device drivers, were being sold in the China market. USB to serial drivers for most serial RS232 devices. Download drivers for most types of USB to serial adapters and converters. Prolific PL-2303 Driver Setup Installer for Windows 7 and 8 (32bit and 64bit) - ThinkCentre M72e, M92p, M92. Sweden Switzerland Taiwan Region Thailand Turkey Ukraine United Arab Emirates United Kingdom United States of America Uruguay US Downloads Venezuela Vietnam.
Of course, you can try to manually update the driver at Prolific site:
But, look carefully on this page and you will read an important notice in RED :
Usb Serial Driver Download
Windows 8/8.1/10 are NOT supported in PL-2303HXA and PL-2303XEOL (End Of Life) chip versions.
This is clear: if your device is using an old chip version of PL2303, the drivers not works with W10 (and W8).
As many people, you probably upgrade directly from W7 to W10, and sure, don't know that this problem was already present with W8. It's a shame from Prolific to not support this devices, because they are still used (my LED badges are less than a year old, and use EOL PL-2303 HX). Prolific's guys are fun when they said : 'Prolific recommends to use PL-2303HXD (HX Rev D) or PL2303TA chip.' . Hey, but I can't do that myself !!!
I don't want to send my devices to trash because they are too old (less than a year !) to be supported by W10. May be, a solution will be to use the old W7 drivers version into W10. Not tested... I will try...